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Education and Professional Experience Positions of Previous Laboratory Members Photos of Recent Laboratory Members Genomics and Other Research Data Center for Nutritional Sciences
| Publications (selected) from last 10 years
Li, M., Y. Zhang, Z. Liu, U. Bhardwaj, H. Wang, X. Wang, S. Zhang, J.P.
Liuzzi, S. Chang, R.J. Cousins, W.E. Fisher, F.C. Brunicardi, C.D. Logsdon, C.
Chen, and Q. Yao (2007) Abberant expression of zinc transporter ZIP4 (SLC39A4)
significantly contributes to human pancreatic cancer pathogenesis and
progression. Proc. Natl. Acad. Sci. USA 104:18636-18641.
Liuzzi, J.P., F. Aydemir, H. Nam, M.D. Knutson, and R.J. Cousins (2006)
ZIP14 (SLC39A14) mediates non-transferrin-bound iron uptake into cells. Proc.
Natl. Acad. Sci. USA 103:13612-13617.
Cousins, R.J., J.P. Liuzzi, and L.A. Lichten (2006) Mammalian zinc
transport, trafficking, and signals. J. Biol. Chem. 281:24085-24089.
Aydemir, T.B., R.K. Blanchard, and R.J. Cousins (2006) Zinc
supplementation of young men alters metallothionein, zinc transporter, and
cytokine gene expression in leukocyte populations. Proc. Natl. Acad. Sci. USA
103:1699-1704.
Liuzzi, J.P., L.A. Lichten, S. Rivera, R.K. Blanchard, T.B. Aydemir, M.D.
Knutson, T. Ganz, and R.J. Cousins (2005) Interleukin-6 regulates the zinc
transporter ZIP14 in liver and contributes to the hypozincemia of the
acute-phase response. Proc. Natl. Acad. Sci. USA 102:6843-6848.
Liuzzi, J.P. and R.J. Cousins (2004) Mammalian zinc transporters. Annu.
REv. Nutr. 24:151-72.
Liuzzi, J.P., J.A. Bobo, L.A. Lichten, D.A. Samuelson, and R.J. Cousins
(2004) Responsive transporter genes within the murine intestinal-pancreatic axis
form a basis of zinc homeostasis. Proc. Natl. Acad. Sci. USA
101:14355-14360.
Cousins, R.J., R.K. Blanchard, M.P. Popp, L. Liu, J, Cao, J.B. Moore, and
C.L. Green (2003) A global view of the selectivity of zinc deprivation and
excess on genes expressed in human THP‑1 mononuclear cells. Proc. Natl.
Acad. Sci. USA 100:6952-6957.
Cousins, R.J., R.K. Blanchard, J. B. Moore, L. Cui, C.L. Green, J.P.
Liuzzi, J. Cao and J.A. Bobo (2003) Regulation of zinc metabolism and genomic
outcomes. J. Nutr. 133:1521S-1526S.
Moore,
J.B., R.K. Blanchard and R.J. Cousins (2003) Dietary zinc modulates gene
expression in murine thymus: Results from a comprehensive differential display
screening. Proc. Natl. Acad. Sci. USA 100: 3883-3888.
Liuzzi, J.P., J.A. Bobo, L. Cui, R.J. McMahon and R.J. Cousins (2003)
Zinc transporters 1, 2 and 4 are differentially expressed and localized in rats
during pregnancy and lactation. J. Nutr. 342-351.
Cui, L., R.K. Blanchard and R.J. Cousins (2003) The permissive effect of
zinc deficiency on uroguanylin and inducible nitric oxide synthase gene
upregulation in rat intestine induced by interleukin 1α is rapidly reversed by
zinc repletion. J. Nutr. 133:51-56. Lanningham-Foster,
L., C.L. Green, B. Langkamp-Henken, B.A. Davis, K.T. Nguyen, B.S. Bender and
R.J. Cousins (2002) Overexpression of CRIP in transgenic mice alters cytokine
patterns and the immune response. Am. J. Physiol. 282:E1197-E1203. Moore, J.B.,
R.K. Blanchard, W.T. McCormack and R.J. Cousins (2001) cDNA array analysis
identifies thymic LCK as upregulated in moderate murine zinc deficiency before
T-lymphocyte population changes. J. Nutr. 131:3189-3196. Blanchard, R.K.,
J.B. Moore, C.L. Green and R.J. Cousins (2001) Modulation of intestinal gene
expression by dietary zinc status: Effectiveness of cDNA arrays for expression
profiling of a single nutrient deficiency. Proc. Natl. Acad. Sci. USA
98:13507-13513. Cousins, R.J.
(2001) Zinc Transporters. In: Encyclopedia of Molecular Medicine, vol.
5 (T.E. Creighton, ed.), John Wiley & Sons, New York, pp. 3431-3434. Cao, J., J.A.
Bobo, J. P. Liuzzi and R.J. Cousins (2001) Effects of intracellular zinc
depletion on metallothionein and ZIP2 transporter expression and apoptosis.
J. Leukocyte Biol. 70:559-566. Cui, L., R.K.
Blanchard and R.J. Cousins (2001) Dietary zinc deficiency increases uroguanylin
accumulation in rat kidney. Kidney Int. 59:1424-1431. Liuzzi, J.P.,
R.K. Blanchard and R.J. Cousins (2001) Differential regulation of zinc
transporter 1, 2, and 4 mRNA expression by dietary zinc in rats. J. Nutr.
131:46 52. Kim, A.H., C.T.
Sheline, M. Tian, T. Higashi, R.J. McMahon, R.J. Cousins, and D.W. Choi (2000)
L type Ca(2+) channel mediated Zn(2+) toxicity and modulation by ZnT 1 in PC12
cells. Brain Res. 886:99 107. Cui, L., R.K.
Blanchard, L.M. Coy and R.J. Cousins (2000) Prouroguanylin overproduction and
localization in the intestine of zinc deficient rats. J. Nutr.
130:2726-2732. Cousins, R.J.
(2000) Integrative aspects of zinc metabolism and function: Underwood Memorial
Lecture. In: Trace Elements in Man and Animals 10: Proceedings of the 10th
International Symposium on Trace Elements in Man and Animals (Roussel, A.M.,
R.A. Anderson, and A.E. Favier, eds.), Plenum, New York, pp. 1-7. Cao, J. and
R.J. Cousins (2000) Metallothionein mRNA in monocytes and peripheral blood
mononuclear cells and in cells from dried blood spots increases after zinc
supplementation of men. J. Nutr. 130: 2180 2187. Cousins, R.J.
and L. Lanningham-Foster (2000) Regulation of cysteine-rich intestinal protein,
a zinc finger protein, by mediators of the immune response. J. Infect. Dis.
182:S81-S84. Blanchard, R.K.
and R.J. Cousins (2000) Regulation of intestinal gene expression by dietary
zinc: Induction of uroguanylin mRNA by zinc deficiency. J. Nutr.
130:1393S-1398S Cousins, R.J.
and R.J. McMahon (2000) Integrative aspects of zinc transporters. J. Nutr.
130:1384S 1387S. Davis, S.R. and R.J. Cousins (2000) Metallothionein expression in
animals: A physiological perspective on function. J. Nutr.
130:1085-1088. Cousins, R.J.
(1999) Nutritional regulation of gene expression, chapter 36. In: Modern
Nutrition in Health and Disease, 9th ed. (Shils, M.E., J.A. Olson, M. Shike
and A.C. Ross, eds.), Williams & Wilkins, Baltimore, pp. 573-584. Davis, B.A.,
R.K. Blanchard, L. Lanningham Foster and R.J. Cousins (1998) Structural
characterization of the rat cysteine rich intestinal protein gene and
overexpression of this LIM only protein in transgenic mice. DNA Cell Biol.
17:1057-1064. Davis, S.R., R.J. McMahon and R.J. Cousins (1998) Metallothionein
knockout and transgenic mice exhibit altered intestinal processing of zinc with
uniform zinc-dependent zinc transporter-1 (ZnT-1) expression. J. Nutr.
128:825-831. McMahon, R.J.
and R.J. Cousins (1998) Regulation of the zinc transporter ZnT 1 by dietary
zinc. Proc. Natl. Acad. Sci. USA 95:4841-4846. Sullivan, V.K.,
F.R. Burnett and R.J. Cousins (1998) Metallothionein expression is increased in
monocytes and erythrocytes of young men during zinc supplementation. J. Nutr.
128:707-713. McMahon, R.J.
and R.J. Cousins (1998) Mammalian zinc transporters. J. Nutr.
128:667-670. Cousins, R.J.
(1998) A role of zinc in the regulation of gene expression. Proc. Nutr. Soc.
57:307-311. For more publications, see
listing
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